오윤배 교수님의 새 연구, “Letter to the Editor: Application of a human stereotactic system for image-guided deep brain stimulation neurosurgery in a swine model”가 Clinical Neurology 분야 IF 상위 10% 이내 저널(406개 중 20위) ‘Brain Stimulation’에 게재되었습니다.
Title: Letter to the Editor: Application of a human stereotactic system for image-guided deep brain stimulation neurosurgery in a swine model
The gyrencephalic swine brain closely resembles human neuroanatomy, rendering it an increasingly popular translational model for stereotactic procedures like deep brain stimulation (DBS) [1, 2]. However, significant challenges limit its full translatability to human stereotactic neurosurgery. Variable frontal sinus pneumatization complicates external landmark-based targeting, oblique ear canals preclude standard ear-bar fixation, and the lack of swine-specific neuroimaging software often necessitates custom data pipelines [1, 3]. Although some studies [1, 2, 4, 5] have integrated commercial human DBS planning software into swine workflows, the translatability of these approaches remained limited by the need for head immobilization, manual adjustments of target coordinates with suboptimal accuracy, or custom software or hardware requirements. To address these limitations, we present the first fully integrated swine DBS workflow enabling MRI-guided direct targeting using a commercially available human stereotactic frame and clinical DBS planning software. We further demonstrate, for the first time, tractography64 guided DBS targeting in swine. Except for minor modifications to the stereotactic system’s skull anchor key, the rest of the system – including the head frame – remained entirely unmodified. This methodology replicates standard clinical DBS workflows, thereby aligning large-animal neurosurgical research more closely with human practice.